{"id":2526,"date":"2025-05-08T07:10:15","date_gmt":"2025-05-08T07:10:15","guid":{"rendered":"https:\/\/www.biogenera.com\/mygenera\/"},"modified":"2025-10-16T11:45:09","modified_gmt":"2025-10-16T11:45:09","slug":"mygenera","status":"publish","type":"page","link":"https:\/\/www.biogenera.com\/en\/mygenera\/","title":{"rendered":"MyGenera"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2526\" class=\"elementor elementor-2526\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5e6df7b e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-parent\" data-id=\"5e6df7b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div data-wpr-particles=\"{&quot;particles&quot;:{&quot;number&quot;:{&quot;value&quot;:80,&quot;density&quot;:{&quot;enable&quot;:true,&quot;value_area&quot;:800}},&quot;color&quot;:{&quot;value&quot;:&quot;#000000&quot;},&quot;shape&quot;:{&quot;type&quot;:&quot;circle&quot;,&quot;stroke&quot;:{&quot;width&quot;:0,&quot;color&quot;:&quot;#000000&quot;},&quot;polygon&quot;:{&quot;nb_sides&quot;:5},&quot;image&quot;:{&quot;src&quot;:&quot;img\/github.svg&quot;,&quot;width&quot;:100,&quot;height&quot;:100}},&quot;opacity&quot;:{&quot;value&quot;:0.5,&quot;random&quot;:false,&quot;anim&quot;:{&quot;enable&quot;:false,&quot;speed&quot;:1,&quot;opacity_min&quot;:0.1,&quot;sync&quot;:false}},&quot;size&quot;:{&quot;value&quot;:3,&quot;random&quot;:true,&quot;anim&quot;:{&quot;enable&quot;:false,&quot;speed&quot;:40,&quot;size_min&quot;:0.1,&quot;sync&quot;:false}},&quot;line_linked&quot;:{&quot;enable&quot;:true,&quot;distance&quot;:150,&quot;color&quot;:&quot;#000000&quot;,&quot;opacity&quot;:0.4,&quot;width&quot;:1},&quot;move&quot;:{&quot;enable&quot;:true,&quot;speed&quot;:6,&quot;direction&quot;:&quot;none&quot;,&quot;random&quot;:false,&quot;straight&quot;:false,&quot;out_mode&quot;:&quot;out&quot;,&quot;bounce&quot;:false,&quot;attract&quot;:{&quot;enable&quot;:false,&quot;rotateX&quot;:600,&quot;rotateY&quot;:1200}}},&quot;interactivity&quot;:{&quot;detect_on&quot;:&quot;window&quot;,&quot;events&quot;:{&quot;onhover&quot;:{&quot;enable&quot;:true,&quot;mode&quot;:&quot;repulse&quot;},&quot;onclick&quot;:{&quot;enable&quot;:true,&quot;mode&quot;:&quot;push&quot;},&quot;resize&quot;:true},&quot;modes&quot;:{&quot;grab&quot;:{&quot;distance&quot;:400,&quot;line_linked&quot;:{&quot;opacity&quot;:1}},&quot;bubble&quot;:{&quot;distance&quot;:400,&quot;size&quot;:40,&quot;duration&quot;:2,&quot;opacity&quot;:8,&quot;speed&quot;:3},&quot;repulse&quot;:{&quot;distance&quot;:200,&quot;duration&quot;:0.4},&quot;push&quot;:{&quot;particles_nb&quot;:4},&quot;remove&quot;:{&quot;particles_nb&quot;:2}}},&quot;retina_detect&quot;:true}\" particle-source=\"wpr_particle_json_custom\" class=\"elementor-element elementor-element-9b1de52 e-con-full wpr-particle-yes e-flex wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"9b1de52\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3502d26 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"3502d26\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0<\/p><p><span style=\"box-sizing: border-box; margin: 0px; padding: 0px;\">La piattaforma\u00a0<strong>MyGenera\u2122<\/strong>, grazie al suo processo bioinformatico basato su una propriet\u00e0 intellettuale della societ\u00e0, permette la rapida identificazione di nuovi AG-PNA con il suo unico meccanismo d\u2019azione ed \u00e8 applicabile a tutte le aree terapeutiche in cui \u00e8 possibile intervenire silenziando i singoli geni responsabili della malattia.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ea4b3b1 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-parent\" data-id=\"ea4b3b1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-3ca9b1e e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"3ca9b1e\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-d133db2 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"d133db2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-d7bb144 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"d7bb144\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-635dffe elementor-widget elementor-widget-heading\" data-id=\"635dffe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">L\u2019innovazione di<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-24cc8ad elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"24cc8ad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1191\" height=\"472\" src=\"https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/05\/LogoMyGeneraTM_Transp.png\" class=\"attachment-full size-full wp-image-1865\" alt=\"\" srcset=\"https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/05\/LogoMyGeneraTM_Transp.png 1191w, https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/05\/LogoMyGeneraTM_Transp-300x119.png 300w, https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/05\/LogoMyGeneraTM_Transp-1024x406.png 1024w, https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/05\/LogoMyGeneraTM_Transp-768x304.png 768w\" sizes=\"(max-width: 1191px) 100vw, 1191px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3605b87 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"3605b87\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-c847202 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"c847202\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-31ec344 elementor-widget elementor-widget-image\" data-id=\"31ec344\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"261\" height=\"240\" src=\"https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/05\/Icona01_Sviluppo.png\" class=\"attachment-large size-large wp-image-1873\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0938f00 elementor-widget elementor-widget-text-editor\" data-id=\"0938f00\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tSviluppo di farmaci oligonucleotidi gene-specifici\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-db99600 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"db99600\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c4390df elementor-widget elementor-widget-image\" data-id=\"c4390df\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"261\" height=\"240\" src=\"https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/05\/Icona02_Tempi.png\" class=\"attachment-large size-large wp-image-1880\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d24097f elementor-widget elementor-widget-text-editor\" data-id=\"d24097f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tTempi di identificazione del farmaco ridotti rispetto ai metodi convenzionali\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-454d71f e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"454d71f\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-245a9c7 elementor-widget elementor-widget-image\" data-id=\"245a9c7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"261\" height=\"240\" src=\"https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/05\/Icona03_Farmaco.png\" class=\"attachment-large size-large wp-image-1879\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dad866a elementor-widget elementor-widget-text-editor\" data-id=\"dad866a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tMigliore efficacia del farmaco\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4dfdd2d e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"4dfdd2d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-318991a elementor-widget elementor-widget-image\" data-id=\"318991a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"261\" height=\"240\" src=\"https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/05\/Icona04_Tossicita.png\" class=\"attachment-large size-large wp-image-1878\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5094d23 elementor-widget elementor-widget-text-editor\" data-id=\"5094d23\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tRidotta o assente tossicit\u00e0 della terapia\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6c2eda5 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-parent\" data-id=\"6c2eda5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-4ac9535 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"4ac9535\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-d332882 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"d332882\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-fe7fea6 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"fe7fea6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_offset&quot;:100,&quot;sticky_anchor_link_offset&quot;:130,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;],&quot;sticky_effects_offset&quot;:0}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3b0e311 elementor-widget elementor-widget-heading\" data-id=\"3b0e311\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Le terapie gene-specifiche e il loro meccanismo <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-71d12c4 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"71d12c4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La piattaforma MyGenera\u2122 consente l\u2019identificazione rapida di nuovi candidati farmaci oligonucleotidi anti-gene (Ag-PNA) (indicati in rosso) che bloccano in modo specifico l\u2019attivit\u00e0 del gene patologico direttamente alla sua origine.<\/p><p>La nuova classe di farmaci Ag-PNA \u00e8 caratterizzata da una breve sequenza di DNA chimicamente modificato che agisce alla fonte su un unico gene bersaglio patologico, direttamente inibendo il processo di trascrizione.<\/p><p>Questo approccio differisce dal tradizionale approccio degli oligonucleotidi \u201cantisenso\u201d, poich\u00e9 inibisce la trascrizione del DNA in RNA (approccio anti-gene) invece di inibire la traduzione dell\u2019RNA in proteina (approccio antisenso).<\/p><p>\u00a0<\/p><h2 style=\"color: #2b2c2e; font-family: Poppins, sans-serif; font-weight: 600; line-height: 1.2; font-size: clamp(30px, 10px + 1.5625vw, 40px); text-align: center; background-color: #f1f1f2;\" data-elementor-setting-key=\"title\" data-pen-placeholder=\"Digita qui...\">Applicazioni<\/h2><p>L\u2019unicit\u00e0 del meccanismo d\u2019azione della piattaforma MyGenera<sup>TM<\/sup>\u00a0\u00e8 applicabile a tutte le aree terapeutiche sulle quali \u00e8 possibile agire silenziando i singoli geni responsabili della malattia.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d328447 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"d328447\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-4221b05 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"4221b05\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b4cbf5d elementor-widget elementor-widget-heading\" data-id=\"b4cbf5d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">01<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c5fa21f elementor-widget elementor-widget-heading\" data-id=\"c5fa21f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Oligonucleotide<br>anti-gene specifico \n(Oligo AG-PNA)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0444d2b elementor-widget elementor-widget-image\" data-id=\"0444d2b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"345\" src=\"https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/04\/Meccanismo_DnaComposto-1024x442.png\" class=\"attachment-large size-large wp-image-1597\" alt=\"\" srcset=\"https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/04\/Meccanismo_DnaComposto-1024x442.png 1024w, https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/04\/Meccanismo_DnaComposto-300x129.png 300w, https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/04\/Meccanismo_DnaComposto-768x331.png 768w, https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/04\/Meccanismo_DnaComposto.png 1076w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4596d86 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"4596d86\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Gene bersaglio (due copie per cellula)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2ac5271 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"2ac5271\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>L\u2019oligonucleotide gene-specifico agisce legandosi in modo selettivo e potente ad un filamento della sequenza di DNA complementare contenuta nel gene bersaglio. Il legame avviene ad un filamento della struttura aperta del DNA del gene bersaglio attivo, bloccandone cos\u00ec la trascrizione.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9c2a0e7 elementor-widget elementor-widget-image\" data-id=\"9c2a0e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;motion_fx_devices&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"180\" height=\"184\" src=\"https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/05\/Meccanismo_Freccia.png\" class=\"attachment-large size-large wp-image-2085\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6dad3ce e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"6dad3ce\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-df09e54 elementor-widget elementor-widget-heading\" data-id=\"df09e54\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">02<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fa0326d elementor-widget elementor-widget-heading\" data-id=\"fa0326d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Azione Farmacologica<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-746e0a4 elementor-widget elementor-widget-image\" data-id=\"746e0a4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"207\" src=\"https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/04\/Meccanismo_SoloDNA2-1024x265.png\" class=\"attachment-large size-large wp-image-1600\" alt=\"\" srcset=\"https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/04\/Meccanismo_SoloDNA2-1024x265.png 1024w, https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/04\/Meccanismo_SoloDNA2-300x78.png 300w, https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/04\/Meccanismo_SoloDNA2-768x198.png 768w, https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/04\/Meccanismo_SoloDNA2.png 1076w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-df590a7 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"df590a7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\u00a0mRNA (migliaia di copie)\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-047e80a elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"047e80a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>AG-PNA inibisce in modo specifico la trascrizione del gene bersaglio bloccando la produzione di migliaia di copie di mRNA<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f393389 elementor-widget elementor-widget-image\" data-id=\"f393389\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"180\" height=\"184\" src=\"https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/05\/Meccanismo_Freccia.png\" class=\"attachment-large size-large wp-image-2085\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b50b7cf e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"b50b7cf\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ca95d9f elementor-widget elementor-widget-heading\" data-id=\"ca95d9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">03<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8793e17 elementor-widget elementor-widget-heading\" data-id=\"8793e17\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: clamp(30px, 10px + 1.5625vw, 40px)\">Azione Farmacologica<\/span><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b44dccb elementor-widget elementor-widget-image\" data-id=\"b44dccb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"521\" height=\"385\" src=\"https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/04\/Meccanismo_SoloProteina.png\" class=\"attachment-large size-large wp-image-1610\" alt=\"\" srcset=\"https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/04\/Meccanismo_SoloProteina.png 521w, https:\/\/www.biogenera.com\/wp-content\/uploads\/2025\/04\/Meccanismo_SoloProteina-300x222.png 300w\" sizes=\"(max-width: 521px) 100vw, 521px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-25ee746 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"25ee746\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tProteina (migliaia di copie)\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ee71ec4 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"ee71ec4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Di conseguenza, l&#8217;inibizione della trascrizione porta anche ad un&#8217;inibizione della produzione di migliaia di copie di proteine (inibizione della traduzone).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u00a0 La piattaforma\u00a0MyGenera&#x2122;, grazie al suo processo bioinformatico basato su una propriet\u00e0 intellettuale della societ\u00e0, permette la rapida identificazione di nuovi AG-PNA con il suo unico meccanismo d\u2019azione ed \u00e8 applicabile a tutte le aree terapeutiche in cui \u00e8 possibile intervenire silenziando i singoli geni responsabili della malattia. L\u2019innovazione di Sviluppo di farmaci oligonucleotidi gene-specifici Tempi di identificazione del farmaco ridotti rispetto ai metodi convenzionali Migliore efficacia del farmaco Ridotta o assente tossicit\u00e0 della terapia Le terapie gene-specifiche e il loro meccanismo La piattaforma MyGenera&#x2122; consente l\u2019identificazione rapida di nuovi candidati farmaci oligonucleotidi anti-gene (Ag-PNA) (indicati in rosso) che bloccano in modo specifico l\u2019attivit\u00e0 del gene patologico direttamente alla sua origine. La nuova classe di farmaci Ag-PNA \u00e8 caratterizzata da una breve sequenza di DNA chimicamente modificato che agisce alla fonte su un unico gene bersaglio patologico, direttamente inibendo il processo di trascrizione. Questo approccio differisce dal tradizionale approccio degli oligonucleotidi \u201cantisenso\u201d, poich\u00e9 inibisce la trascrizione del DNA in RNA (approccio anti-gene) invece di inibire la traduzione dell\u2019RNA in proteina (approccio antisenso). \u00a0 Applicazioni L\u2019unicit\u00e0 del meccanismo d\u2019azione della piattaforma MyGeneraTM\u00a0\u00e8 applicabile a tutte le aree terapeutiche sulle quali \u00e8 possibile agire silenziando i singoli geni responsabili della malattia. 01 Oligonucleotideanti-gene specifico (Oligo AG-PNA) Gene bersaglio (due copie per cellula) L\u2019oligonucleotide gene-specifico agisce legandosi in modo selettivo e potente ad un filamento della sequenza di DNA complementare contenuta nel gene bersaglio. Il legame avviene ad un filamento della struttura aperta del DNA del gene bersaglio attivo, bloccandone cos\u00ec la trascrizione. 02 Azione Farmacologica \u00a0mRNA (migliaia di copie) AG-PNA inibisce in modo specifico la trascrizione del gene bersaglio bloccando la produzione di migliaia di copie di mRNA 03 Azione Farmacologica Proteina (migliaia di copie) Di conseguenza, l&#8217;inibizione della trascrizione porta anche ad un&#8217;inibizione della produzione di migliaia di copie di proteine (inibizione della traduzone).<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"footnotes":""},"class_list":["post-2526","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.biogenera.com\/en\/wp-json\/wp\/v2\/pages\/2526","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biogenera.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.biogenera.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.biogenera.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biogenera.com\/en\/wp-json\/wp\/v2\/comments?post=2526"}],"version-history":[{"count":73,"href":"https:\/\/www.biogenera.com\/en\/wp-json\/wp\/v2\/pages\/2526\/revisions"}],"predecessor-version":[{"id":3004,"href":"https:\/\/www.biogenera.com\/en\/wp-json\/wp\/v2\/pages\/2526\/revisions\/3004"}],"wp:attachment":[{"href":"https:\/\/www.biogenera.com\/en\/wp-json\/wp\/v2\/media?parent=2526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}